RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
miR-199a-5p
RNA ID
RNA Type
miRNA
Alteration Pattern
dysregulation
Species
homo sapiens
Detection Methods
microRNA Target Prediction And Pathway Analysis; TaqMan miRNA Assay For Individual miRNAs etc.
Target
NA
Pathway
NA
PubMed ID
Title
Discovery and validation of extracellular/circulating microRNAs during idiopathic pulmonary fibrosis disease progression
Year
2015
Function
"47 Significantly differentially expressed serum miRNAs were found in rapid progressive or slowly progressive IPF patients compared to healthy controls, including 21 up-regulated miRNAs and 26 down-regulated miRNAs. Bioinformatic analysis by DIANA-mirPath demonstrated that 53 KEGG biological processes were significantly enriched among differentially expressed serum miRNAs, including TGF-Beta signaling pathway, MAPK signaling pathway, PI3K-Akt signaling pathway, Wnt signaling pathway, HIF-1 signaling pathway, regulation of actin cytoskeleton, Jak-STAT signaling pathway, Notch signaling pathway, and Cytokine-cytokine receptor interaction. MiR-21, miR-199a-5p, and miR-200c were significantly increased in serums of IPF patients while miR-31, let-7a, and let-7d were significantly under expressed in serums of IPF patients compared to healthy controls."